Market access strategy for a new CAR-T therapy in multiple myeloma

The challenge

Our client was developing a CAR-T therapy in Multiple Myeloma (MM) across multiple lines of therapy. One of the indications being explored was its use as a maintenance therapy in MM after autologous stem cell transplantation (ASCT).

In order to inform their market access strategy and maximise the access / reimbursement opportunity in transplant not intended (TNI) newly diagnosed multiple myeloma (NDMM), our client needed to identify the key value drivers and optimal clinical trial design.

The solution
Following an initial scoping and desk research phase, we conducted focus groups with payers and KOLs in the EU and Canada in order to understand the MM maintenance landscape, the perceived value of our client’s new therapy, the optimal clinical trial design, and the potential pricing and reimbursement impact.

The outcomes
We were able to determine the optimal clinical trial design for our client’s CAR-T therapy including the value of maintenance therapy, the optimal patient population, comparator selection and key endpoints critical for success. In addition, we evaluated the likely positioning within TNI NDMM and assessed the anticipated reimbursement challenges and opportunities in each market as wells as potential solutions. The results of our study gave our client the insights they needed in the following four areas:

Clinical and access landscape: Current management
Value of Product X: Scenario perceptions and reactions to expected results
Access and reimbursement: Expected HTA outcomes and P&R implications
Recommendations and next steps: Deep dive by market

Find out more about our experience in market access

Case study: How we helped to inform the market access strategy for a new CAR-T therapy in multiple myeloma

Sign up to receive Rapport