Home Resources How we investigated healthcare professionals’ perceptions of the impact of MDD with clinically relevant insomnia symptoms (CRIS) on patients quality of life.

How we investigated healthcare professionals’ perceptions of the impact of MDD with clinically relevant insomnia symptoms (CRIS) on patients quality of life.

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The challenge

MDD is often linked with insomnia, affecting patients’ QoL through anxiety, sleep deprivation, impaired productivity, and other symptoms. We surveyed healthcare professionals’ globally to explore the impact of MDD with severe insomnia on patients and health economics, as well as satisfaction with treatment strategies and patterns..

Our solution

An online survey was distributed to primary care physicians, psychiatrists, physician’s assistants, and nurse practitioners from the US, Canada, France, Germany, Italy, Spain, UK, Belgium, Brazil, and Australia.

The respondents had to

  • have primary responsibility for managing ≥4 adults with MDD-CRIS (including in the last 3 months)
  • have been practising for between 2 and 35 years
  • have been spending ≥50% of time in clinical
  • not manage 100% treatment-resistant patients.

The survey took ~40 minutes, and comprised four patient record forms (PRFs), from patients that:

  • have been diagnosed with MDD-CRIS
  • are not enrolled in clinical trials
  • are not treatment resistant
  • could now be deceased.
The results

Based on their experience managing patients with MDD with insomnia, the physicians reported that the QoL and productivity of patients with MDD-CRIS is significantly worse than those with MDD and mild insomnia. Area such as employability were highly affected seeing an average of 67 days off work for patients with MDD-CRIS across the EMEA region and across the whole sample, up to 47% of patients were unemployed – this is highly problematic when treatment incurs direct costs on most local European healthcare systems. The physicians also agreed that treatment of MDD gets harder as severity of insomnia increases.  All factors necessitate a need for further research into MDD, insomnia and their interrelationship as well as novel treatments/strategies.

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